黄连素合成中缩合/还原反应甲基杂质的分离与二维核磁解析
Isolation and 2D-NMR analysis of methylation impurity formed in the condensation/reduction reaction in the synthesis of berberine
张祥明 1赵宗敏 1张小金 1古志国1
作者信息
- 1. 江西富祥药业股份有限公司 景德镇 333000
- 折叠
摘要
黄连素是一种具有显著抑菌作用的重要生物碱.利用柱层析对其合成中缩合/还原反应甲基杂质进行分离,并用核磁氢谱 1H-NMR、碳谱 13C-NMR,二维核磁相关谱 1H-1HCOSY、HSQC、HMBC以及DEPT135 o对分离的甲基杂质进行了结构归属解析.
Abstract
Berberine is an important alkaloid with significant antibacterial effects.The methyl impurity in the condensation/reduction reaction during its synthesis was isolated by column chromatography and analyzed by 1H-NMR,13C-NMR,1H-1HCOSY,HSQC,HMBC and DEPT135 o.
关键词
黄连素/杂质/柱层析/核磁共振二维谱解析Key words
berberine/impurity/column chromatography/2D-NMR analysis引用本文复制引用
出版年
2024
NETL
NSTL
万方数据