Objective:To optimize the extraction process of water-soluble active ingredients in the formula of Lotse Kunsel.Methods:The yield of dry extract,the transfer rate of hydroxysafflower yellow A and the yield of solid content extracted by ethyl acetate were used as indexes.The effects of water addition ratio,extraction time and extraction times on the extraction process were investigated.L934 orthogonal test was used to optimize the extraction process.Results:The best process was to add 12 times of water and extract three times for 1 hour each.Conclusion:The optimized process is stable and reliable and the transfer rate of active ingredients is high.
Lotse Kunselextraction processorthogonal testhydroxysafflower yellow A
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