Clinical application of low-dose aspirin combined with low molecular weight heparin in atypical antiphospholipid syndrome in obstetrics
Objective:To explore the clinical application effect of low-dose aspirin combined with low molecular weight heparin in atypical antiphospholipid syndrome in obstetrics.Methods:From June 2021 to June 2022,80 patients with atypical antiphospholipid syndrome treated in the outpatient clinic were collected and random number table method was used to divide them into a control group and an observation group with 40 cases in each group.The control group was injected with low molecular weight heparin calcium 5 000 IU/time,once a day.The observation group was treated with low dose aspirin 75～100 mg/time,once a day on the basis of the control group.The pregnancy outcome,negative conversion of antiphospholipid antibodies,incidence of placental dysfunction,neonatal weight,Apgar score 5 min after birth,neonatal asphyxia rate,and changes in thromboelastogram before and after treatment were compared between the two groups.Results:The pregnancy loss rate and premature delivery rate in the observation group were 1 case(2.50%)and 2(5.00%),respectively,which were lower than those in the control group 4 cases(10.00%)and 7 cases(17.50%),respectively,and difference between groups was statistically significant(P<0.05).The negative conversion rate of antiphospholipid antibodies in the observation group was 37 cases(92.50%),which was higher than 30 cases(75.00%)in the control group(P<0.05);the total incidence of placental dysfunction in the observation group was 13 cases(32.50%),which was lower than 22 cases(55.00%)in the control group(P<0.05).The neonatal weight and Apgar score 5 min after birth in the observation group were significantly higher than those in the control group(P<0.05).The R level in the observation group was higher than that in the control group(P<0.05).Conclusion:Low dose aspirin can improve the pregnancy outcome of obstetric patients with atypical antiphospholipid syndrome,increase the negative conversion rate of antiphospholipid antibody,reduce the risk of placental dysfunction,improve the prognosis of newborns,and regulate coagulation factors,which is worthy of clinical recommendation.
atypical antiphospholipid syndrome in obstetricsaspirinpregnancy outcomeplacental dysfunction
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