冠心病患者PCI术后LOX-1变化在社区综合管理中的作用
Role of LOX-1 changes in coronary heart disease patients after PCI in the community comprehensive management
薛红梅 1陆军 1张庆勇2
作者信息
- 1. 上海市徐汇区华泾镇社区卫生服务中心全科门诊,上海 200231
- 2. 上海市第九人民医院心血管内科,上海 200011
- 折叠
摘要
目的:分析冠心病(CHD)患者经皮冠状动脉介入(PCI)术后 6个月和 12个月凝集素样氧化型低密度脂蛋白受体 1(LOX-1)的动态变化情况,评估综合管理康复治疗的疗效.方法:收集 2021 年 1 月至 2022 年 12 月门诊60 例冠心病患者PCI治疗前和治疗后 6 个月和 12 个月的血清样本.患者平均年龄59.4 岁,被分为对照组和干预组,每组 30 例.对照组中男性 14 例,女性 16 例;干预组中男性 17 例,女性 13 例.采用酶联免疫吸附测定方法检测LOX-1含量,并统计主要心脏不良事件(MACE)发生率.结果:干预组在 6 个月和 12 个月时LOX-1 水平显著低于对照组以及术前水平,差异均有统计学意义(均P＜0.05),且在 6 个月时效果最为显著.12 个月时干预组患者的MACE发生率明显低于对照组,且对照组与干预组中无MACE患者的LOX-1 水平显著低于有MACE的患者.结论:LOX-1 的水平与CHD患者PCI术后及远期MACE发生率密切相关,社区综合管理需要加强LOX-1 的干预,减少MACE的发生,因此LOX-1 的动态水平可作为综合管理康复治疗疗效评估指标之一.
Abstract
Objective:To analyze the dynamic changes of lectin-like oxidized low-density lipoprotein receptor-1(LOX-1)at 6 and 12 months after percutaneous coronary intervention(PCI)in patients with coronary heart disease(CHD),and to evaluate the efficacy of comprehensive management of rehabilitation.Methods:Serum samples of 60 CHD patients in the clinic from January 2021 to December 2022 were collected before treatment and 6 and 12 months after treatment.The average age of the patients was 59.4 years old,and they were divided into a control group and an intervention group with 30 cases each.In the control group there were 14 males and 16 females;in the intervention group there were 17 males and 13 females.Enzyme-linked immunosorbent assay was used to detect the content of LOX-1 and the incidence of major adverse cardiac events(MACE)was also calculated.Results:LOX-1 level was significantly lower in the intervention group at 6 and 12 months than that in the control group and before surgery,and the difference was statistically significant(P<0.05),and the effect was most significant at 6 months.At 12 months,the incidence of MACE in the intervention group was significantly lower than that in the control group,and LOX-1 level in the patients without MACE was significantly lower than that in the patients with MACE in the both control and intervention groups.Conclusion:The level of LOX-1 is closely related to the incidence of MACE in patients with CHD after PCI and in the long term,community comprehensive management needs to be strengthened the intervention of LOX-1 to reduce the incidence of MACE.Therefore,the dynamic level of LOX-1 can be used as one of the evaluation indexes of the efficacy of comprehensive management rehabilitation therapy.
关键词
冠心病/经皮冠状动脉介入术/凝集素样氧化型低密度脂蛋白受体/主要心脏不良事件Key words
coronary heart disease/percutaneous coronary intervention/lectin-like oxidized low-density lipoprotein receptor-1/major adverse cardiac event引用本文复制引用
基金项目
徐汇区医学科研项目(SHXH202021)
出版年
2024
NETL
NSTL
万方数据