In vitro evaluation of the anti-inflammatory and anti-acne effects of Qudou formulae extract
Objective:To explore the effects of Qudou formulae(QF)extract on the epidermal barrier repair,anti-inflammatory,sebum control and antibacterial function.Methods:The epidermal barrier repair,anti-inflammatory,sebum control and antibacterial effects of QF extract were evaluated by detecting its effects on sodium dodecyl sulfate(SDS)-induced proliferation of HaCaT cell damage model,lipopolysaccharide(LPS)-induced nitric oxide(NO)production in RAW 264.7 cells,proliferation of SZ95 cells and neutral lipid synthesis,and inhibition of Staphylococcus aureus(S.aureus)and Propionibacterium acnes(P.acnes).Results:QF extract could improve the survival rate of SDS-induced HaCaT cells,inhibit the secretion of NO from LPS-treated RAW 264.7 cells,promote the growth of SZ95 cells and inhibit its neutral lipid synthesis,and had the inhibitory activity against S.aureus and P.acnes.Conclusion:QF extract has significant epidermal barrier repair,anti-inflammatory,oil control and antibacterial effects,and is expected to become a new raw material for Chinese medicine acne skin care products.
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