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一种新型功效组合物的油敏性皮肤舒缓功效研究

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目的:多方面评估一种新型功效组合物五环精华对油敏性皮肤的舒缓功效.方法:以上海地区 34名 18~60 岁的油敏性肤质健康女性受试者为研究对象,采用自体前后对照的方法来评估长期使用五环精华对油敏性皮肤的舒缓功效.结果:受试者连续使用五环精华 4 周后,皮肤的多项生理指标得到显著改善,包括角质层含水量增加 13.29%,经表皮失水下降 11.72%,温度下降 1.91%,油脂分泌量减少 21.21%,红斑指数下降 7.70%,黑色素指数下降 4.54%,色度a*值下降 5.84%,色度L*值增加 5.68%,乳酸刺激 2.5 min后评分下降 58.16%(均P<0.01).结论:对于油敏性皮肤,五环精华能够有效增加皮肤含水量,减少油脂分泌和色素沉着,缓解炎症状态,提亮肤色且刺激性小,显著改善皮肤屏障功能,说明其具有皮肤舒缓和修复功效.
Study on the soothing effects of a novel efficacy complex on the skin of individuals with oily sensitivity
Objective:To comprehensively evaluate the soothing effects of a novel efficacy complex(referred to as"Penta-Ring essence")on the skin of individuals with oily sensitivity.Methods:An in vivo experimental approach with 34 healthy female subjects aged 18-60 years with oily skin from the Shanghai area was employed.The soothing effect of a long-term use of Penta-Ring essence on oily and sensitive skin was evaluated by a method of autologous before-and-after control.Results:A number of physiological indicators of the skin were significantly improved after the Penta-Ring essence was continuously used for 4 weeks,including 13.29%increase in the water content of the stratum corneum,11.72%decrease transepidermal water loss,1.91%decrease in skin temperature,21.21%decrease in skin sebum,7.70%decrease in skin E value,4.54%decrease in M value,5.84%decrease in skin chroma a* value,5.68%increase in skin chroma L* value and 58.16%decrease in the score after 2.5 min lactate irritation(all P<0.01).Conclusion:For oily and sensitive skin,the Penta-Ring essence can effectively increase skin hydration,reduce oil secretion and pigmentation,relieve inflammation,brighten skin tone with minimal irritation and significantly improve skin barrier function,which demonstrate its efficacy in skin soothing and repair.

Penta-Ring essenceoil-sensitive skinskin barriertransepidermal water losssoothing effects

陈宪策、季小凡、马彦云、刘庆梅

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复旦大学生命科学学院 上海 200438

上海市宝山区吴淞中心医院皮肤科 上海 201900

复旦大学人类表型组研究院 上海 200438

复旦大学附属华山医院皮肤科 上海 200040

上海市皮肤病研究所 上海 200040

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五环精华 油敏性皮肤 皮肤屏障 经表皮失水 舒缓功效

上海市科学技术委员会资助的基地项目复旦大学横向课题

19DZ2250500SGH1323010

2024

上海医药
上海医药行业协会

上海医药

影响因子:0.781
ISSN:1006-1533
年,卷(期):2024.45(11)
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