药品口感评价新工具:电子舌
A new tool for drug taste evaluation:electronic tongue
廖萍 1曹萌 1陈一飞 1董正龙 1戚淑叶 2宁保明 2陈桂良1
作者信息
- 1. 上海药品审评核查中心 上海 201210
- 2. 中国食品药品检定研究院 北京 102629
- 折叠
摘要
药品口感会显著影响其临床应用效果.传统的药品口感评价方法包括人口尝试验、动物偏好试验和体外分析方法(如体外溶出试验)等.本文介绍一种新型药品口感评价工具——电子舌.电子舌运用体外仿生学技术,以样品整体味觉信息输出药品口感情况,具有较好的客观性,检测速度也快,可避免人口尝试验中的潜在安全风险和主观因素影响.本文介绍电子舌的发展情况及其在药品口感评价中的应用进展,并提出相关建议.
Abstract
The taste of drugs can significantly affect the clinical application effect.The traditional evaluation methods for the taste of drugs include human mouth test,animal preference test,and in vitro analysis methods such as in vitro dissolution test.A new tool for drug taste evaluation,electronic tongue,was introduced in this paper.Electronic tongue is an in vitro bionics technology,which can output the taste of drugs with the overall taste information of samples.It has good objectivity and fast detection speed,and can avoid the potential safety risks and subjective factors in human mouth test.This paper introduces the development of electronic tongue and its application in drug taste evaluation,and puts forward some suggestions for further application and development of electronic tongue.
关键词
药品口感/电子舌/味觉Key words
drug taste/electronic tongue/gustation引用本文复制引用
出版年
2024
NETL
NSTL
万方数据