阿帕替尼致高血压的文献病例分析
Literature case analysis of hypertension induced by apatinib
王春晖 1吴薇 1张皓云 2许青1
作者信息
- 1. 复旦大学附属中山医院 上海 200032
- 2. 复旦大学附属中山医院 上海 200032;复旦大学药学院 上海 201203
- 折叠
摘要
目的:探讨阿帕替尼致高血压的临床特点,为临床防治提供参考.方法:从知网、PubMed等国内外数据库检索阿帕替尼致高血压的病例报告文献,分析患者基本情况、抗肿瘤治疗方案、高血压发生、干预和转归等情况.结果:收集到 26篇文献,患者共 30例;男性 12例,女性 18例;年龄 16～93岁,平均 58岁.阿帕替尼日剂量 500 mg和250 mg最普遍.19例高血压发生的中位时间为 14(7,30)d,其中 13例(68%)出现在服药 15 d内.3级及以上高血压 16 例(53%),手足综合征和蛋白尿是常见的并发不良反应.绝大多数患者经阿帕替尼剂量调整和/或降压治疗后血压控制平稳,仅 4 例患者停用阿帕替尼.结论:阿帕替尼致高血压多在用药 2 周内出现,3 级及以上高血压常见,但多数患者的血压经阿帕替尼停药或减量治疗和应用降压药后可控.
Abstract
Objective:To investigate the clinical features of apatinib-associated hypertension to provide reference for clinical prevention and treatment.Methods:The case report literature related to apatinib induced hypertension was retrieved from domestic and foreign databases such as CNKI and PubMed and basic characteristics of patients,anti-tumor regimen,situation of hypertension,interventions and outcomes were analyzed.Results:A total of 26 literature and 30 patients were involved in the analysis,including 12 males and 18 females.Their ages were between 16 to 93 years old with a mean of 58.The most common daily doses of apatinib were 500 mg or 250 mg.The median onset time of hypertension in 19 cases was 14(7,30)days,in which 13 cases(68%)occurred within 15 days after taking apatinib.Hypertension with grade 3 or above was observed in 16 cases(53%),hand-foot syndrome and proteinuria were common adverse reactions.Most patients had stable blood pressure control after the adjustment of apatinib dose and/or antihypertensive therapy,and apatinib was discontinued only in 4 patients.Conclusion:Apatinib-associated hypertension usually occurs within 2 weeks after medication,and the hypertension with grade 3 or above is common,but the blood pressure of most patients can be controlled after stopping apatinib or reducing its dose and applying antihypertensive drugs.
关键词
阿帕替尼/血管生成抑制剂/高血压/药物不良反应Key words
apatinib/angiogenesis inhibitors/hypertension/adverse drug reaction引用本文复制引用
出版年
2024
NETL
NSTL
万方数据