Effect of aspirin on cardio-cerebral vascular events in hypertensive patients over 60 years old in Anting Community,Shanghai
Objective:To investigate the effect of aspirin on cardio-cerebral vascular events in hypertensive patients over 60 years old.Methods:From January 2018 to December 2018 4 488 hypertensive patients were selected from the chronic diseases management in Anting Community Health Service Center in Shanghai,among them,there were 2 075 males(46.2% ),2 413 females(53.8% )and the average age was(69.76±6.80)years.Based on the condition of taking aspirin,the patients were divided into an aspirin group with 910 cases and a non-aspirin group with 3 578 cases.The following up ended until December 31,2020,and clinical endpoint events were recorded during follow-up.Kaplan-Meier survival curve and Cox regression mode were used to evaluate the effect of aspirin on cardio-cerebral vascular events.Results:Kaplan-Meier survival curve analysis showed that the risk of cardio-cerebral vascular events,cerebral infarction and all-cause death significantly reduced in the aspirin group(RR=0.38,95% CI:0.21-0.66,P=0.001,RR=0.29,95% CI:0.15-0.55,P＜0.001 and RR=0.19,95% CI:0.07-0.51,P=0.001),the risk of myocardial infarction significantly increased(RR=22.66,95% CI:1.9-266.93,P=0.013).Conclusion:Long-term use of aspirin in hypertensive patients can reduce the incidence of cardio-cerebral vascular events,and does not increase the risk of cerebral hemorrhage.More evidence-based medical evidence is needed for further validation through prospective studies.
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