首页|基于Granada-Ⅱ分类系统评价临床应用曲美他嗪的药物相关问题

基于Granada-Ⅱ分类系统评价临床应用曲美他嗪的药物相关问题

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目的:分析曲美他嗪在临床应用中存在的药物相关问题(DRPs),促进临床合理用药.方法:随机选取应用曲美他嗪的住院患者401例并收集患者相关信息,以药品说明书、药典中有关曲美他嗪适应证、禁忌证、用法用量和注意事项的规定、相关指南等为依据,使用Granada-Ⅱ分类法对应用曲美他嗪的相关性问题进行分析评价.结果:401例患者共有263例发生了DRPs,主要表现为DRP2(超适应证用药和给药时机不适宜)121例、DRP5(禁忌证用药)63例、DRP6(日累积剂量超说明书推荐剂量上限)48例、DRP4(日累积剂量不足)31例.结论:曲美他嗪临床应用中普遍存在不合理情况,建议医师严格把握其适应证和禁忌证,根据患者情况调整给药剂量,还可借助信息化手段完善前置医嘱审核,限制其不合理用药情况,保障患者用药安全.
Evaluation of drug-related problems in the clinical use of trimetazidine based on the Granada-Ⅱ classification system
Objective:To analyze the drug-related problems(DRPs)of trimetazidine in clinical application,and to promote the rational use of medication in the clinic.Methods:Four hundred and one inpatients who applied trimetazidine were randomly selected and the relevant information of patients was collected.The relevance of the application of trimetazidine was analyzed and evaluated using the Granada-Ⅱ classification method based on the drug instruction,pharmacopoeia regulations on the indications,contraindications,dosages and precautions of trimetazidine and relevant guidelines.Results:A total of 263 DRPs occurred in 401 patients,which were mainly manifested as DRP2(over-indication of use and inappropriate timing of administration)in 121 cases,DRP5(contraindication to use)in 63 cases,DRP6(daily cumulative dose exceeding the upper limit of the recommended dose in the specification)in 48 cases,and DRP4(insufficient daily cumulative dose)in 31 cases.Conclusion:The clinical application of trimetazidine is generally unreasonable,it is recommended that physicians should strictly grasp its indications and contraindications,adjust the dosage according to the patient's condition,and also can use information technology to improve the audit of the front medical prescription,limit the irrational use of medication and ensure the safety of patient's medication.

KEY WRODS trimetazidineGranada-Ⅱ classification methoddrug-related problemsrational drug use

杨颖、李梦媛

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高淳人民医院药学部 南京 210000

南京医科大学第二附属医院药学部 南京 210011

曲美他嗪 Granada-Ⅱ分类法 药物相关问题 合理用药

南京药学会-常州四药医院药学科研基金资助项目

2019YX005

2024

上海医药
上海医药行业协会

上海医药

影响因子:0.781
ISSN:1006-1533
年,卷(期):2024.45(15)