Effects of bovine lung surfactant combined with CPAP on pulmonary ventilation and oxygenation function in children with NRDS
Objective:To investigate the effect of bovine-derived pulmonary surfactant combined with continuous positive airway pressure(CPAP)on pulmonary ventilation and oxygenation in children with neonatal respiratory distress syndrome(NRDS).Methods:Ninety-three children with NRDS were randomly divided into an experimental group(n=46)and a conventional group(n=47)based on a random number table method.The conventional group was treated with CPAP,while the experimental group was additionally treated with bovine lung surfactant for injection on this basis.The efficacy,lung ventilation and oxygenation function and inflammatory response were compared between the two groups 7 days after treatment.Results:The total effective rate,the time to peak tidal expiratory flow as a proportion of expiratory time,the force expiratory volume in 1 second and the oxygenation index were higher,while the airway resistance,the respiratory index,the levels of interleukin-6 and procalcitonin were lower in the experimental group than the conventional group(P<0.05).Conclusion:The combination of bovine lung surfactant and CPAP for the treatment of NRDS has a definite therapeutic effect,which can reduce inflammatory reactions and enhance oxygenation and pulmonary ventilation in children.
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