舍曲林联合经颅直流电刺激治疗青少年抑郁症伴有非自杀性自伤行为的疗效研究
Efficacy of sertraline combined with transcranial direct current stimulation in the treatment of adolescent depression with non-suicidal self-injurious behavior
曾霞 1陈明哲 1龙蕾 2王阳3
作者信息
- 1. 宜春市第三人民医院 儿少心理科 宜春 336000
- 2. 宜春市第三人民医院 女二病房 宜春 336000
- 3. 宜春市第三人民医院 心理科 宜春 336000
- 折叠
摘要
目的:探究舍曲林联合经颅直流电刺激(tDCS)治疗青少年抑郁症伴有非自杀性自伤行为(NSSI)的疗效.方法:选取抑郁症伴NSSI青少年患者 60 例,随机分为对照组和观察组,各 30 例.对照组采用舍曲林,观察组在此基础上加用tDCS治疗.比较两组治疗前后的汉密尔顿抑郁量表17 项(HAMD-17)、抑郁自评量表(SDS)、青少年非自杀性自伤行为评定问卷(ANSAQ)、不良反应.结果:治疗 4 周后,观察组HAMD-17、SDS评分,ANSAQ行为、功能评分及总分均低于对照组和治疗前(P＜0.05).两组不良反应比较,差异无统计学意义(P＞0.05).结论:舍曲林联合tDCS可减轻抑郁症伴有NSSI青少年患者的抑郁症状,降低其ANSAQ评分,且未增加不良反应.
Abstract
Objective:To explore the efficacy of sertraline combined with transcranial direct current stimulation(tDCS)in treating depression with non-suicidal self-injury(NSSI)in adolescents.Methods:Sixty adolescents with depression and NSSI were randomly divided into a control group and an observation group with 30 cases each.The control group was treated with sertraline,while the observation group with sertraline combined with tDCS.The Hamilton depression rating scale 17-item(HAMD-17),self-rating depression scale(SDS),adolescent non-suicidal self-injury behavior assessment questionnaire(ANSAQ),and the incidence of adverse reactions were compared before and after treatment.Results:The HAMD-17,SDS scores,ANSAQ behavior and function scores and total scores after 4 weeks of treatment were lower in the observation group than the control group and after treatment than before(P<0.05).There were no significant differences between the two groups in the incidence of adverse reactions(P>0.05).Conclusion:Sertraline combined with tDCS can effectively reduce depressive symptoms and ANSAQ scores in the adolescents and will not increase the incidence of adverse reactions.
关键词
青少年/抑郁症/非自杀性自伤行为/经颅直流电刺激/不良反应Key words
adolescent/depression/non-suicidal self-injurious/transcranial direct current stimulation/adverse effects引用本文复制引用
出版年
2024
NETL
NSTL
万方数据