Efficacy of sertraline combined with transcranial direct current stimulation in the treatment of adolescent depression with non-suicidal self-injurious behavior
Objective:To explore the efficacy of sertraline combined with transcranial direct current stimulation(tDCS)in treating depression with non-suicidal self-injury(NSSI)in adolescents.Methods:Sixty adolescents with depression and NSSI were randomly divided into a control group and an observation group with 30 cases each.The control group was treated with sertraline,while the observation group with sertraline combined with tDCS.The Hamilton depression rating scale 17-item(HAMD-17),self-rating depression scale(SDS),adolescent non-suicidal self-injury behavior assessment questionnaire(ANSAQ),and the incidence of adverse reactions were compared before and after treatment.Results:The HAMD-17,SDS scores,ANSAQ behavior and function scores and total scores after 4 weeks of treatment were lower in the observation group than the control group and after treatment than before(P<0.05).There were no significant differences between the two groups in the incidence of adverse reactions(P>0.05).Conclusion:Sertraline combined with tDCS can effectively reduce depressive symptoms and ANSAQ scores in the adolescents and will not increase the incidence of adverse reactions.
adolescentdepressionnon-suicidal self-injurioustranscranial direct current stimulationadverse effects
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