Objective:To analyze the dynamic changes in serum non-enzymatic antioxidant concentrations in hospitalized patients with schizophrenia during the treatment.Methods:One hundred and thirty-three cases of the hospitalized patients with schizophrenia were selected as an observation group and the concentrations of their non-enzymatic antioxidant at different time points were determined and compared with those in different age subgroups and 120 healthy residents taken as a controls group.Results:In terms of comparison between groups,the concentrations of serum total bilirubin(TBil)and uric acid(UA)were higher in the observation group than the control group at the time of admission,and were lower in the observation group than the control group after 4 or 8 weeks of treatment(P<0.05).The concentrations of albumin(ALB)were lower in the observation group than the control group after 8 weeks of treatment(P<0.05),and there were no significant differences in ALB concentrations between the two groups at admission and after 4 weeks.In terms of intra-group comparison,the concentrations of TBil and UA in the observation group were all lower at 4 or 8 weeks of treatment than at admission(P<0.05).The ALB concentration of patients aged 40-50 years was lower than that of patients aged 18-28 years and 29-39 years at admission and after 4 weeks of treatment(P<0.05),and the of the rest of the indexes there were no statistically significant differences in the rest of the indicators among the different age groups.Conclusion:Before treatment,patients with schizophrenia were in a state of high oxidative stress;after treatment,the overall antioxidant capacity of the patients was lower than that of the healthy population,and they needed to adhere to the treatment.Patients in the older age groups,whose antioxidant capacity was even weaker,should adhere to the standardized treatment even more to improve the overall prognosis.
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