Objective:To analyze the clinical characteristics and risk factors of liver injury induced by amiodarone,and explore early warning methods.Methods:The cases who used amiodarone in our hospital from January 2017 to March 2023 were retrospectively analyzed,and the cases with liver injury were clinically summarized and the associated risk factors were also analyzed.Results:A total of 1 775 cases used amiodarone were included,in which 71 patients developed liver injury after using amiodarone.The proportion of mild,moderate,and severe liver injury was 60.56%,26.76%and 7.04%,respectively,and 71.8%of liver injury occurred within 1 day after medication,and 54.9%of liver injury could be recovered within 6 days after drug withdrawal.The combined use of antimicrobial drugs and the concurrent cardiovascular disease were risk factors for liver injury induced by amiodarone.Conclusion:When using amiodarone,early monitoring of liver function should be strengthened,and pharmaceutical care should be taken for high-risk patients to reduce the incidence of drug-induced liver injury.
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