Pathogenic microorganisms are always a threat and challenge to global public health security due to their high incidence,wide spread and rapid mutation.In recent decades,the development of antiviral drugs has developed rapidly.In particular,fluorine-containing antiviral drugs have made a number of major breakthroughs in the fight against chronic viral infection,and also greatly improved the quality of life of the majority of patients.In this paper,the research progress of fluorine-containing drugs against hepatitis B virus,hepatitis C virus,influenza virus,human immunodeficiency virus and corona virus disease 2019 was reviewed by reviewing relevant literature,in order to provide theoretical basis for the development and clinical use of antiviral drugs.
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