早期断奶应激影响仔猪肠道发育及其调控的研究进展
Advancements in Early Weaning Stress Affecting Intestinal Development of Piglets and Its Regulation
穆钊坤 1周加义 1昝庚秀 1王修启1
作者信息
- 1. 猪禽种业全国重点实验室,华南农业大学动物科学学院,广东省动物营养调控重点实验室,国家生猪种业工程技术研究中心,广东 广州 510642
- 折叠
摘要
早期断奶是提高养猪生产效益的重要措施,但同时也增加了仔猪应激性腹泻率和死淘率.断奶期间,仔猪采食量降低,能量摄入严重不足,干细胞驱动的肠道上皮更新受阻,肠道结构和屏障功能被破坏,该过程与Wnt、Notch和mTOC1等多种干细胞命运决定信号和营养感应信号的传导异常相关.针对特定靶点,补充营养/非营养性添加剂是保障仔猪顺利度过断奶阶段的有效干预策略.文章从干细胞层面就断奶对仔猪肠道发育的影响及其可能的机制进行归纳总结,并系统介绍了营养素和非营养素在调控肠道上皮结构和功能完整性方面的作用,以期为仔猪早期断奶应激防治提供理论依据.
Abstract
Early weaning is an important measure to improve pig production efficiency,but it also increases the incidence of stress diarrhea and mortality of piglets.During the weaning period,piglets experi-ence reduced feed intake,which results in severe energy intake deficits,impaired intestinal stem cell(ISC)-driven renewal of the epithelium,and disruption of intestinal structure and barrier func-tion.This process is associated with aberrant transduction of multiple ISC fate-determining sig-nals and nutrient-sensing signals such as Wnt,Notch,and mTOC1.Targeting specific signals with nutri-tional/non-nutritional additives is an effective strategy to ensure the smooth transition of piglets during the weaning stage.The paper summarizes the impacts of weaning on piglet intestinal development and its pos-sible mechanisms from the perspective of ISCs,and also systematically introduces the roles of nutrients and non-nutrients in regulating intestinal epithelial structure and functional integrity,which aims to provide a theoretical foundation for preventing and control of early weaning stress in piglets.
关键词
早期断奶应激/肠上皮发育/肠道干细胞/能量代谢/营养/非营养添加剂Key words
early weaning stress/intestinal epithelial development/intestinal stem cells/energy metabo-lism/nutritional/non-nutritional additives引用本文复制引用
出版年
2025
国家科技期刊平台
NSTL
维普
万方数据