Advancements in Early Weaning Stress Affecting Intestinal Development of Piglets and Its Regulation
Early weaning is an important measure to improve pig production efficiency,but it also increases the incidence of stress diarrhea and mortality of piglets.During the weaning period,piglets experi-ence reduced feed intake,which results in severe energy intake deficits,impaired intestinal stem cell(ISC)-driven renewal of the epithelium,and disruption of intestinal structure and barrier func-tion.This process is associated with aberrant transduction of multiple ISC fate-determining sig-nals and nutrient-sensing signals such as Wnt,Notch,and mTOC1.Targeting specific signals with nutri-tional/non-nutritional additives is an effective strategy to ensure the smooth transition of piglets during the weaning stage.The paper summarizes the impacts of weaning on piglet intestinal development and its pos-sible mechanisms from the perspective of ISCs,and also systematically introduces the roles of nutrients and non-nutrients in regulating intestinal epithelial structure and functional integrity,which aims to provide a theoretical foundation for preventing and control of early weaning stress in piglets.
early weaning stressintestinal epithelial developmentintestinal stem cellsenergy metabo-lismnutritional/non-nutritional additives
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维普
