世界复合医学2024,Vol.10Issue(3) :195-198.DOI:10.11966/j.issn.2095-994X.2024.10.03.50

有毒乌头类中药炮制与配伍减毒机制的研究进展

Research Progress on the Processing and Compatibility of Toxic Aconitum Traditional Chinese Medicines to Reduce Toxicity

孙继华
世界复合医学2024,Vol.10Issue(3) :195-198.DOI:10.11966/j.issn.2095-994X.2024.10.03.50

有毒乌头类中药炮制与配伍减毒机制的研究进展

Research Progress on the Processing and Compatibility of Toxic Aconitum Traditional Chinese Medicines to Reduce Toxicity

孙继华1
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作者信息

  • 1. 济南市章丘区精神卫生中心,山东济南 250200
  • 折叠

摘要

乌头类中药在我国的药用历史悠久,主要包括草乌、川乌与附子,涵盖诸多生物活性物质.此类中药的中毒剂量与治疗剂量相近,临床治疗窗较窄,在使用时常有中毒事件与不良反应的发生,因此制约其广泛运用.深入探究有毒乌头类中药炮制以及配伍对乌头急性毒性的影响和作用,分析其毒性产生的相关机制,对合理开发乌头类新型制剂、提高乌头类中药的使用安全性有着积极意义,有助于为乌头类中药的合理使用提供有效指导.本文围绕有毒乌头类中药炮制与配伍减毒机制的研究进展予以综述.

Abstract

Aconitum traditional Chinese medicine has a long history of medicinal use in our country,mainly including radix aconiti agrestis,monkshood and aconite,covering many biologically active substances.Since the toxic dose of this type of traditional Chinese medicine is similar to the therapeutic dose,the clinical therapeutic window is narrow,and poisoning events and adverse reactions often occur during use,thus restrict-ing its widespread use.In-depth exploration of the effects and effects of the processing and compatibility of toxic aconitum traditional Chinese medicine on the acute toxicity of aconitum,and the related mechanisms of its toxicity were analyzed.It has positive significance for the rational development of new Aconitum preparations and improving the safety of use of Aconitum traditional Chinese medicines,and helps to provide effective guid-ance for the rational use of Aconitum traditional Chinese medicines.In this paper,the relevent reports are ana-lyzed,and the research progress on the meohanism of processing and compatibility of toxic aconite Chinese medicine is reviewed.

关键词

乌头/中药炮制/配伍减毒

Key words

Aconitum/Traditional Chinese medicine processing/Compatibility and attenuation

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出版年

2024
世界复合医学

世界复合医学

ISSN:
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