Objective To investigate the clinical effect of integrated traditional Chinese and Western Medi-cine in the treatment of upper respiratory tract infection.Methods A total of 66 patients with upper respiratory tract infection who received treatment in the Shunyi Hospital of Beijing Traditional Chinese Medicine Hospital from December 2022 to September 2023 were selected as the study objects,and they were divided into observa-tion group and control group by lottery method,with 33 cases in each group.The control group was treated with oseltamivir and cefuroxime axetil,and the observation group was treated with Yinlian detoxification decoction on the basis of the control group.The therapeutic effect of the two groups was compared.Results The total effec-tive rate of the observation group was 96.97%,higher than 78.79%of the control group,and the difference was statistically significant(χ2=5.121,P=0.024).The disappearance time of fever,sore throat,headache,cough and phlegm and nasal obstruction in observation group were shorter than those in control group,and the differences were statistically significant(all P<0.05).After treatment,the interleukin-10 level in the observation group was higher than that in the control group,while procalcitonin and C-reactive protein levels were lower than those in the control group,and the differences were statistically significant(all P<0.05).After treatment,the levels of im-munoglobulin A,immunoglobulin G and immunoglobulin M in the observation group were higher than those in the control group,and the differences were statistically significant(all P<0.05).There was no significant differ-ence in the incidence of adverse reactions between the two groups(P>0.05).Conclusion In the treatment of up-per respiratory tract infection,although conventional Western medicine treatment can alleviate symptoms,it is highly likely to relapse after stopping medication.Adding Yinlian detoxification decoction can better improve the immune response and inflammatory response of patients and thus achieve better therapeutic effect.