PCT、CRP、IL-6用于预测骨科术后感染性发热的价值研究

Value of PCT,CRP and IL-6 in Predicting Infectious Fever after Orthopedic Surgery

谭龙 ¹杨晓艇 ¹刘忠敏²

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作者信息

1. 广东省东莞市谢岗医院骨科,广东东莞 523590
2. 广东省东莞市谢岗医院麻醉科,广东东莞 523590
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摘要

目的探讨降钙素原(procalcitonin,PCT)、C反应蛋白(C-reactive protein,CRP)、白细胞介素-6(interleukin-6,IL-6)用于预测骨科术后感染性发热的价值.方法选取2022年7月—2023年9月广东省东莞市谢岗医院收治的60例骨科术后感染性发热患者为研究组,60例健康体检人群为对照组.比较两组PCT、CRP、IL-6水平.使用受试者操作特征曲线预测骨科术后感染性发热情况.结果研究组的PCT、CRP、IL-6 水平均高于对照组,差异有统计学意义(P均<0.05).PCT、CRP、IL-6诊断骨科术后感染性发热的曲线下面积分别0.943、0.727、0.776,灵敏度分别为81.25%、62.50%、75.00%,特异度分别为97.73%、70.45%、56.82%.结论 PCT、CRP、IL-6用于预测骨科术后感染性发热具有一定价值,其中PCT灵敏度、特异度高于其他炎症指标.

Abstract

Objective To investigate the value of procalcitonin(PCT),C-reactive protein(CRP)and inter-leukin-6(IL-6)in predicting infectious fever after orthopedic surgery.Methods Sixty patients with infectious fever after orthopedic surgery admitted to Dongguan Xiegang Hospital from July 2022 to September 2023 were selected as the study group,and sixty healthy people were selected as the control group.The levels of PCT,CRP and IL-6 were compared between the two groups.Receiver operating characteristic curve was used to predict in-fectious fever after orthopedic surgery.Results The levels of PCT,CRP and IL-6 in the study group were higher than those in the control group,and the differences were statistically significant(all P<0.05).The area under curve of PCT,CRP and IL-6 in diagnosing infectious fever after orthopedic surgery were 0.943,0.727 and 0.776,respectively.The sensitivity was 81.25%,62.50%and 75.00%,and the specificity was 97.73%,70.45%and 56.82%,respectively.Conclusion PCT,CRP and IL-6 have certain value in predicting infectious fever af-ter orthopedic surgery,and the sensitivity and specificity of PCT are higher than other inflammatory indicators.

关键词

降钙素原/C反应蛋白/白细胞介素-6/骨科/术后感染/发热

Key words

Procalcitonin/C-reactive protein/Interleukin-6/Department of Orthopedics/Postoperative infection/Fever

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基金项目

2021年东莞市社会发展科技项目(20211800902842)

出版年

2024

世界复合医学

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