Objective To investigate the effect of Yiqi Ditan Tongluo Decoction in the clinical treatment of patients with acute cerebral infarction(ACI)(Zhongjingluo Qi deficiency and phlegm stasis syndrome).Meth-ods From October 2021 to October 2023,219 patients with ACI(Zhongjingluo Qi deficiency and phlegm stasis syndrome)admitted to Jurong Hospital of Traditional Chinese Medicine were selected as the research objects.According to different treatment methods,they were divided into control group and observation group.The con-trol group was treated with routine Western medicine(n=109),and the observation group was treated with Yiqi Ditan Tongluo Decoction(n=110)on the basis of routine treatment.The cerebral artery hemodynamics indexes(pulsitility index,arterial blood flow resistance index),serum adhesion molecule levels(soluble vascular cell ad-hesion molecule,soluble cell adhesion molecules-1),neurological deficit score,disability score,Traditional Chi-nese Medicine syndrome score and clinical effect were analyzed and compared between the two groups.Results After 2 weeks of treatment,the National Institutes of Health Stroke Scale score and Modified Rankin Scale score of the observation group were lower than those of the control group,and the differences were statistically signifi-cant(both P<0.05).After 2 weeks of treatment,the symptomatic manifestations of patients in both groups were significantly reduced,and the decrease in Traditional Chinese Medicine syndrome scores was greater in the ob-servation group,and the differences were statistically significant(all P<0.05).After 2 weeks of treatment,the pulsitility index and arterial blood flow resistance index of the observation group were smaller than those of the control group,and the differences were statistically significant(both P<0.05).After 2 weeks of treatment,the se-rum adhesion molecule levels of the observation group were lower than those of the control group,and the differ-ences were statistically significant(both P<0.05).The total effective rate of treatment in the observation group was 96.36%(106/110),which was higher than 85.32%(93/109)in the control group,and the difference was sta-tistically significant(χ2=8.045,P=0.005).Conclusion The therapeutic effect of Yiqi Ditan Tongluo Decoction on ACI(Zhongjingluo Qi deficiency and phlegm stasis syndrome)patients is accurate,which can promote the re-covery of patients'neurological function and reduce the symptomatic manifestations.