Objective To explore the application value of average volume assured pressure support(AVAPS)in emergency chronic obstructive pulmonary disease(COPD)with CO2 retention.Methods A total of 86 patients with COPD complicated with CO2 retention admitted to the Department of Emergency of Yongjia County People's Hospital from April 2020 to May 2023 were retrospectively selected as the research objects.The patients were divided into two groups according to different treatment methods,with 43 cases in each group.The control group received synchronous intermittent forced ventilation,and the study group received AVAPS.The levels of blood gas analysis and ventilator ventilation parameters were compared between the two groups.Results Ventilation for 24 h,two groups of partial pressure of blood oxygen,blood oxygen saturation levels are higher than ventilation,partial pressure of carbon dioxide level was lower than ventilation before,the levels of blood oxygen partial pressure[(89.36±2.17)mmHg]and blood oxygen saturation[(96.42±2.69)%]in the study group were higher than those in the control group[(76.42±2.31)mmHg,(87.52±2.37)%],the level of carbon dioxide partial pressure in the observation group was[(53.42±3.43)mmHg],which was lower than[(67.83±2.76)mmHg]in the control group,and the differences were statistically significant(t=26.773,16.279,21.463,all P<0.05).After 24 hours of ventilation,the tidal volume of the study group was higher than that of the control group,and the ventilation volume and peak airway pressure were lower than those of the control group,and the differences were statistically significant(all P<0.05).Conclusion The application of AVAPS in clinical emergency COPD patients with CO2 retention is beneficial to improve the blood gas index level and ventilation parameter index of patients,so as to regulate the prognosis of patients.