首页|Blood eosinophils and mortality in patients with acute respiratory distress syndrome:A propensity score matching analysis

Blood eosinophils and mortality in patients with acute respiratory distress syndrome:A propensity score matching analysis

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
BACKGROUND:The effect of blood eosinophils (EOSs) on mortality in acute respiratory distress syndrome (ARDS) patients and whether corticosteroids affect this effect are unclear. METHODS:The Medical Information Mart for Intensive Care III database (version 1.4) was used to extract data. Patients with ARDS were selected for inclusion. Cox regression models using the backward stepwise method and propensity score matching (PSM) were used to assess the relationship between blood EOS counts and 28-day mortality. RESULTS:A total of 2,567 patients with ARDS were included, and the 28-day mortality rate was 24.19％. The crude 28-day mortality was significantly lower in patients with EOS counts ≥2％ (18.60％[85/457] vs. 25.40％ [536/2,110], P=0.002) than in those with EOS counts <2％. In the Cox regression model, the EOS counts ≥2％ showed a significant association with the decreased 28-day mortality (hazard ratio [HR] 0.731; 95％ confidence interval [95％ CI] 0.581–0.921, P=0.008). In the corticosteroid non-use subgroup, EOS counts ≥2％ was significantly related to decreased 28-day mortality (HR 0.697, 95％ CI 0.535–0.909, P=0.008), but the result was not significant in the corticosteroid non-use subgroup model (P=0.860). A total of 457 well-matched pairs were obtained by a 1:1 matching algorithm after PSM. The 28-day mortality remained significantly lower in the EOS counts ≥2％ group (18.60％ [85/457] vs. 26.70％ [122/457], P=0.003). CONCLUSIONS Higher EOS counts are related to lower 28-day mortality in ARDS patients, and this relationship can be counteracted by using corticosteroids.

Critical careAcute respiratory distress syndromeEosinophilsMortalityCorticosteroid

Hao-tian Chen、Jian-feng Xu、Xiao-xia Huang、Ni-ya Zhou、Yong-kui Wang、Yue Mao

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Department of Emergency Intensive Care Unit,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China

Department of Respiratory Therapy,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China

Department of Respiratory Medicine,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China

Department of Medical Administration,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China

Department of Cardiology,the Second Affiliated Hospital of Zhejiang University School of Medicine,Hangzhou 310009,China

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2021

10.5847/wjem.j.1920-8642.2021.02.008

世界急诊医学杂志(英文)
浙江大学,浙江大学医学院附属第二医院

世界急诊医学杂志(英文)

CSCDSCI
ISSN：1920-8642
年,卷(期)：2021.12(2)
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