首页|Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke:an over 10-year intensive care survey

Serum procalcitonin levels are associated with rhabdomyolysis following exertional heatstroke:an over 10-year intensive care survey

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  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
BACKGROUND:Heatstroke has become a common emergency event in hospitals.Procalcitonin(PCT)is used as a biomarker of infection in the emergency department(ED),but its role in rhabdomyolysis(RM)following exertional heatstroke(EHS)remains unclear.METHODS:A retrospective cohort study enrolled patients with EHS from the intensive care unit(ICU).We collected RM biomarkers,infiammation markers,critical disease scores at admission,24 h,48 h,and discharge,and 90-day mortality.Correlation analysis,linear regression and curve fitting were used to identify the relationship between PCT and RM.RESULTS:A total of 162 patients were recruited and divided into RM(n=56)and non-RM(n=106)groups.PCT was positively correlated with myoglobin(Mb),acute hepatic injury,disseminated intravascular coagulation(DIC),Sequential Organ Failure Assessment(SOFA)score,and Acute Physiology and Chronic Health Evaluation Ⅱ(APACHE Ⅱ)score,with correlation coefficients of 0.214,0.237,0.285,0.454,and 0.368,respectively(all P＜0.05).Interestingly,the results of curve fitting revealed a nonlinear relationship between PCT and RM,and a two-piecewise linear regression model showed that PCT was related to RM with an odds ratio of 1.3 and a cut-off of＜4.6 ng/mL.Survival analysis revealed that RM was associated with higher mortality compared to non-RM cases(P=0.0093).CONCLUSION:High serum PCT concentrations are associated with RM after EHS in critically ill patients.Elevated PCT concentrations should be interpreted cautiously in patients with EHS in the ED.

ProcalcitoninMyoglobinRhabdomyolysisExertional heatstroke

Li Zhong、Feifei Shuai、Conglin Wang、Lipeng Han、Zhifeng Liu、Ming Wu

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Department of Traditional Chinese Medicine,the First Affiliated Hospital,Guizhou University of Chinese Medicine,Guiyang 550001,China

Department of Medical Critical Care Medicine,General Hospital of Southern Theatre Command of People's Liberation Army,Guangzhou 510010,China

Department of Infection and Critical Care Medicine,Shenzhen Second People's Hospital&First Affiliated Hospital of Shenzhen University,Health Science Center,Shenzhen 518035,China

Department of Nosocomial Infection Prevention and Control,Shenzhen Second People's Hospital,Shenzhen 518035,China

Key Laboratory of Hot Zone Trauma Care and Tissue Repair of People's Liberation Army,General Hospital of Southern Theatre Command of People's Liberation Army,Guangzhou 510010,China

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国家自然科学基金国家自然科学基金国家自然科学基金Sanming Project of Medicine in ShenzhenShenzhen Science and Technology Innovation CommissionShenzhen Second People's Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction ProjectShenzhen Second People's Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction ProjectShenzhen Second People's Hospital Clinical Research Fund of Guangdong Province High-Level Hospital Construction ProjectGuizhou Science and Technology Planning ProjectGuizhou Science and Technology Planning ProjectPhD Startup Fund

820721438187394382360903SZSM20162011JCYJ20190806163603504202033570142023xgyj33570012023yjlcyj022Guizhou ScienceTechnology Cooperation Support[2021]General 41309

2024

10.5847/wjem.j.1920-8642.2024.02.009

世界急诊医学杂志(英文)
浙江大学,浙江大学医学院附属第二医院

世界急诊医学杂志(英文)

ISSN：1920-8642
年,卷(期)：2024.15(1)
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