首页|Assessment of rehabilitation treatment for patients with acute poisoning-induced toxic encephalopathy

Assessment of rehabilitation treatment for patients with acute poisoning-induced toxic encephalopathy

扫码查看
原文链接
  • 国家科技期刊平台
  • NETL
  • NSTL
  • 万方数据
Assessment of rehabilitation treatment for patients with acute poisoning-induced toxic encephalopathy
BACKGROUND:Poisoned patients often suffer damage to multiple systems,and those experiencing central nervous system disorders present more severe conditions,prolonged hospital stays,and increased mortality rates.We aimed to assess the efficacy of rehabilitation interventions for patients with toxic encephalopathy.METHODS:This retrospective,observational,comparative cohort study was performed at the teaching hospital affiliated of Nanjing Medical University,from October 2020 to December 2022.Patients who met the diagnostic criteria for toxic encephalopathy and exclusion criteria were included,and patients were divided into three subgroups according to Glasgow Coma Scale(GCS).Demographic and clinical characteristics were collected.The effect of the rehabilitation intervention on patients were assessed in the improvement of consciousness status(Glasgow Coma Scale[GCS]score),muscle strength and movement and swallowing function(Fugl-Meyer Assessment[FMA]scale,Water Swallow Test[WST],and Standardized Swallowing Assessment[SSA]).Subgroup analysis was based on different toxic species.RESULTS:Out of the 464 patients with toxic encephalopathy,184 cases received rehabilitation treatments.For the severe toxic encephalopathy patients,patients without rehabilitation intervention have a 2.21 times higher risk of death compared to patients with rehabilitation intervention(Hazard ratio[HR]=2.21).Subgroup analysis revealed that rehabilitation intervention significantly increased the survival rate of patients with pesticide poisoning(P=0.02),while no significant improvement was observed in patients with drug/biological agent poisoning(P=0.44).After rehabilitation intervention,significant improvement in GCS and FMA were observed in severe patients with toxic encephalopathy(P<0.01).CONCLUSION:Active rehabilitation intervention for patients exposed to poisons that can potentially cause toxic encephalopathy may improve the prognosis and reduce the mortality rate in clinical practice.

Toxic encephalopathyPoisoningRehabilitationEfficacy

Hao Wu、Yu Zhou、Baogen Xu、Wen Liu、Jinquan Li、Chuhan Zhou、Hao Sun、Yu Zheng

展开 >

Department of Emergency and Critical Care Medicine,Jiangsu Province Hospital/First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China

The Key Laboratory of Modern Toxicology of Ministry of Education,Nanjing Medical University,Nanjing 210000,China

Department of Emergency Medicine,Yancheng Clinical Medical College,Nanjing Medical University,Nanjing 211100,China

Drum Tower Clinical Medical College,Nanjing Medical University,Nanjing Drum Tower Hospital,Nanjing 210008,China

Institute of Poisoning,Nanjing Medical University,Nanjing 210000,China

Center for Rehabilitation Medicine,Jiangsu Province Hospital/First Affiliated Hospital of Nanjing Medical University,Nanjing 210000,China

展开 >

Toxic encephalopathy Poisoning Rehabilitation Efficacy

2024

10.5847/wjem.j.1920-8642.2024.095

世界急诊医学杂志(英文)
浙江大学,浙江大学医学院附属第二医院

世界急诊医学杂志(英文)

ISSN：1920-8642
年,卷(期)：2024.15(6)