Microbial secondary metabolites have important application potential in agriculture,animal husbandry and medicine.This paper briefly reviews the role of microbial secondary metabolites in crop protection and the EU risk assessment framework for metabolites of concern in the management of microbial pesticide registration.The secondary metabolites produced by different microorganisms,including fungi,bacteria and actinomycetes,may be used as insecticides,fungicides and nematocides in plant protection.The EU registration of microbial pesticides places particular emphasis on the safety of microbial secondary metabolites and the need to determine whether the secondary metabolites involved are secondary metabolites of concern.The evaluation of secondary metabolites included toxicity and antimicrobial activity.The risk assessment process consists of 21 steps in four stages.The secondary metabolites of concern identified require further quantitative assessment.
关键词
微生物次生代谢产物/受关切的次生代谢产物/风险评价/欧盟微生物农药登记
Key words
microbial secondary metabolite/metabolites of concern/risk assessment/registration of microbial pesticides
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