To obtain a new suitable industrial route of 3',4'-dichloro-5-fluoro-1,1'-biphenyl-2-amine,which was the key intermediate of bixafen,the synthesis process was optimized.3',4'-Dichloro-5-fluoro-1,1'-biphenyl-2-amine was synthesized using 3,4-dichlorobromobenzene and 2-bromo-4-fluoroaniline as starting material by two steps of grignard and Suzuki coupling reaction.The structure was confirmed by 1H NMR,MS,and the synthesis conditions were optimized.Under the optimal reaction conditions,the total yield of 4'-chloro-2-aminobiphenyl was over 61.9％based on 3,4-dichlorobromobenzene,the purity was 98％.This process has the feature of low cost,high yield and has the prospect of industrial scale manufacture.
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