In order to obtain the three main impurities of dechloroprothioconazole,dethioprothioconazole,and methylprothioconazole in prothioconazole TC,benzyl chloride,prothioconazole were used as starting materials.A synthesis route was designed and the three impurities were synthesized.The impurity content was>97%,and their structure was confirmed by LC-MS and 1H NMR structural characterization.Based on the synthesis route of prothioconazole TC and relevant literature investigation,the possible processes of three impurities were analyzed and speculated.The results can provide a foundation and guidance for the research and process development of prothioconazole.
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