2,6-Dichloro-4-trifluoromethylaniline is an important intermediate that can be used to prepare dyes and pesticides,especially in the field of pesticides.Starting from 4-trifluoromethylaniline,a G1 microchannel reactor was used to construct a preheating,oxychlorination,and cooling process for the continuous synthesis of 2,6-dichloro-4-trifluoromethylaniline.We investigated the effects of process parameters such as temperature,system pressure,material flow rate,and dosage on the reaction in each section.Under optimized conditions,the reaction yield can reach 83.0%and the product content is 99.0%.This synthesis process utilizes the excellent mass and heat transfer performance of microchannel reactors,which not only ensures the safety of the process system but also improves production efficiency,providing a foundation for the updating and iteration of industrial technology.
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