中间体2-氯-4-氟-5-硝基苯甲酸的新合成方法
Novel synthesis of the intermediate 2-chloro-4-fluoro-5-nitrobenzoic acid
王勃 1杜晓华1
作者信息
- 1. 浙江工业大学 化学工程学院,杭州 310014
- 折叠
摘要
探索中间体2-氯-4-氟-5-硝基苯甲酸的新合成方法.从 4-氟苯胺出发,经过盐酸-双氧水体系氯化、重氮化、氰化、硝化-水解串联反应共 4步得到 2-氯-4-氟-5-硝基苯甲酸,纯度 96.2%,总收率 59.2%.新合成方法原材料易得、条件温和,具有工业化应用前景.
Abstract
A new synthesis route of the intermediate 2-chloro-4-fluoro-5-nitrobenzoic acid was explored.Starting from 4-fluoroaniline,2-chloro-4-fluoro-5-nitrobenzoic acid was obtained by six steps,including oxidation-chlorination,diazo-cyanidation,nitration-hydrolysis,with a purity of 96.2%and an overall yield of 59.2%.The new synthesis method has the advantages of easily available raw materials and mild conditions,and is suitable for industrial production.
关键词
4-氟苯胺/2-氯-4-氟-5-硝基苯甲酸/苯嘧磺草胺/新合成方法Key words
4-fluoroaniline/2-chloro-4-fluoro-5-nitrobenzoic acid/saflufenacil/new synthesis method引用本文复制引用
出版年
2024
NETL
NSTL
万方数据