To investigate the control efficacy of metamifop·oxaziclomefone 18%EC against annual weeds in direct-seeding rice fields and the safety to rice growth.A field trial was carried out in 2023 by foliar spray at the 2.5-4 leaf stage of rice and 2-4 leaf stage of annual weeds according to GB/T 17980.40-2000《Pesticide guidelines for the field efficacy trials(Ⅰ)》.The field trial result showed that metamifop·oxaziclomefone 18%EC could effectively control the annual weeds such as Echinochloa crusgalli(L.)Beauv.,Leptochloa chinensis(L.)Nees.,and Digitaria sanguinalis(L.)Scop with the active ingredient dosage of 108.0-135.0 g a.i./hm2.At 30 days after treatment,the weeds quantity and weeds fresh weight control efficacy was 89.07%-92.51%,and 92.00%-94.13%,respectively.Metamifop·oxaziclomefone 18%EC can effectively control annual weeds in direct seeding rice fields,and very safe to rice plants and benefial organisms.