To screen out the best synergistic combination of fluopyram and fludioxonil against Botrytis cinerea.The optimal ratio of fluopyram-fludioxonil mixtures to Botrytis cinerea was determined by mycelium growth inhibition method,and the activity of the optimal ratio was verified by leaf method and field efficacy test.When the mass ratio of fluopyram and fludioxonil was 3∶1,2∶1,1∶1,2∶3,1∶2,2∶5 and 1∶3,they had a synergistic effect,but 2∶3,showed the best synergistic effect,and both in vitro leaf method and field test results showed excellent control effect against the disease at the 25-35 mL/666m2 dosage of fluopyram and fludioxonil 30%SC(2:3).Fluopyram·fludioxonil 30%SC prepared from the 2∶3 mass ratio can effectively control the tomato gray mold disease with the recommended dose 25-35 mL/666m2.