The industrial conventional process for the reduction of 2-[(N-p-chlorophenyl)-3-pyrazoloxy methyl]nitrobenzene(referred to as pyrazole ether)to prepare the key intermediate of hydroxylamine of pyraclostrobin is to use Raney nickel as catalyst and hydrazine hydrate as hydrogen source.This method has high selectivity for hydroxyamide,but the Raney nickel and hydrazine hydrate used in the process are both highly explosive,posing significant safety hazards,and the reaction process is difficult to control.Catalytic hydrogenation has a high atom utilization rate,but it is still difficult to prepare hydroxylamine industrially.By adopting the platinum-carbon catalytic hydrogenation process,the conversion rate of the raw material of pyrazole ether can be>99%,the selectivity of the key intermediate of hydroxylamine of pyraclostrobin can be>99%,with mild process conditions and inherently safer chemical engineering.
关键词
吡唑醚菌酯羟胺关键中间体/催化加氢/化工本质安全
Key words
key intermediate of pyraclostrobin hydroxylamine/catalytic hydrogenation/chemical intrinsic safety
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