摘要
目的:探讨清脑解郁方治疗帕金森病抑郁的临床疗效和安全性及对睡眠质量的影响.方法:选取上海市静安区中医医院脑病科收治的帕金森病抑郁患者76 例作为研究对象,采用随机数字表法分为对照组和观察组,每组 38 例.对照组口服盐酸舍曲林片治疗,观察组口服盐酸舍曲林片+清脑解郁方治疗,分别于治疗前及治疗后第 4、8 周,观察中医证候积分、统一帕金森评定量表(UPDRS)、老年抑郁量表(GDS-15)、汉密尔顿抑郁量表(HAMD-17)、匹兹堡睡眠质量指数量表(PSQI)的评分及差值,进行临床疗效评价和安全性分析.结果:治疗第4、8 周后,观察组GDS-15、HAMD-17、中医证候积分较治疗前均明显改善(P＜0.05).治疗8 周后,观察组PSQI评分优于对照组(P＜0.05),UPDRS评分较治疗前下降明显(P＜0.01).同时,观察组的中医证候总有效率高于对照组(P＜0.05).2 组均未出现严重不良反应.结论:清脑解郁方可改善帕金森病抑郁患者的精神活动、行为情感、运动检查、日常生活能力、睡眠质量及肝气郁结症状.
Abstract
Objective:To investigate the clinical efficacy and safety of Qingnao Jieyu Fang in the treatment of Parkinson's depres-sion,as well as it's impact on sleep quality.Methods:A total of 76 depression patients with Parkinson's disease admitted to the Brain Disease Department of Jing'an District Traditional Chinese Medicine Hospital in Shanghai were selected as the research subjects.They were randomly divided into a control group and an observation group using the random number part method,with 38 cases in each group.The control group was treated with oral sertraline hydrochloride tablets,while the observation group was trea-ted with sertraline hydrochloride tablets and Qingnao Jieyu Fang.The scores and differences of Traditional Chinese Medicine Syn-drome Score,Unified Parkinson's Rating Scale(UPDRS),Geriatric Depression Scale(GDS-15),Hamilton Depression Scale(HAMD-17),and Pittsburgh Sleep Quality Index(PSQI)were observed before and after treatment for 4 and 8 weeks,respective-ly,for clinical efficacy evaluation and safety analysis.Results:After 4 and 8 weeks of treatment,the observation group showed sig-nificant improvements in GDS-15,HAMD-17,and traditional Chinese medicine syndrome scores compared to before treatment(P＜0.05).After 8 weeks of treatment,the PSQI score of the observation group was better than that of the control group(P＜0.05),and the UPDRS score decreased significantly compared to before treatment(P＜0.01).Meanwhile,the total effective rate of traditional Chinese medicine syndromes in the observation group was higher than that in the control group(P＜0.05).No seri-ous adverse reactions were observed in both groups.Conclusion:The Qingnao Jieyu Fang can improve the mental activity,behav-ior and emotions,physical examination,daily living ability,sleep quality,and symptoms of liver qi stagnation in patients with de-pression in Parkinson's disease.
基金项目
上海市西部区域中医联合体2022年度未来计划中医药传承发展项目(XBYLT-WLJH-2023-005)
上海市静安区卫生健康委员会中医专项课题资助项目(2018ZY02)
上海市静安区中医药临床重点专科建设项目(2020-2023年)(JA2020-Z008)
上海市静安区名老中医专家传承创新工作室建设项目(JA2021-MLZZ003)
国家科技期刊平台
NSTL
万方数据