摘要
目的:系统评价桂枝加龙骨牡蛎汤治疗失眠症的临床有效性和安全性.方法:在国家知识基础设施数据库(CNKI)、中国学术期刊数据库(CSPD)、中文科技期刊数据库(CCD)、中国生物医学文献数据库、Pubmed、Web of Science、Embase等网站检索建库至2022 年3 月28 日发表的关于桂枝加龙骨牡蛎汤治疗失眠症的随机对照试验(RCT)文献.由2 名研究员进行文献筛选、资料提取、偏倚分析后,运用RevMan5.3 软件进行Meta分析.结果:最终纳入RCT文献共 17篇,涉及 1 395 例患者.Meta分析结果显示,桂枝加龙骨牡蛎汤的治疗有效率高于对照组OR(95%CI)为 3.93(2.61～5.90),匹兹堡睡眠质量指数量表(PSQI)总分下降高于对照组MD(95%CI)为-2.05(-2.72～-1.38).结论:桂枝加龙骨牡蛎汤可有效提高失眠症治疗有效率,缓解相关症状.但受纳入研究质量影响,该研究结论还有待高质量临床研究验证.
Abstract
Objective:To systematically evaluate the clinical efficacy and safety of Guizhi and Longgu Muli Decoction in the treatment of insomnia.Methods:Randomized controlled trial(RCT)literature about Guizhi and Longgu Muli Decoction about treating insomnia in Cochrane Library,Pubmed,Web of science,Embase,CNKI and CSPD,CCD and Chinese Biomedical Litera-ture Database from the establishment of the databases to March 28,2022 were searched.Two researchers conducted literature screening,data extraction and bias analysis,and then conducted meta-analysis using RevMan5.3 software.Results:A total of 17 RCT articles were included,involving 1 395 patients.Meta analysis results showed that the effective rate of Guizhi and Longgu Muli Decoction was higher than the control group OR(95%CI)3.93(2.61 to 5.90),and the total score of Pittsburgh Sleep Quality Index(PSQI)decreased more than the control group MD(95%CI)-2.05(-2.72 to-1.38).Conclusion:Guizhi and Longgu Muli Decoction can effectively improve the effective rate of insomnia treatment and relieve related symptoms.However,af-fected by the quality of the included study,the research conclusion needs to be verified by high-quality clinical research.
基金项目
国家中医药管理局中医药循证能力提升项目(国中医药科技中药便函[2023]24号)
国家科技期刊平台
NSTL
万方数据