分析疏肝解郁安神汤联合酸枣仁汤对抑郁症伴失眠患者睡眠质量的影响
Analysis of the Effect of Shugan Jieyu Anshen Tang Combined with Suanzaoren Tang on Sleep Quality in Patients with Depression and Insomnia
常晓 1司书博 1张迪1
作者信息
- 1. 山东省淄博市精神卫生中心,淄博,255100
- 折叠
摘要
目的:分析疏肝解郁安神汤联合酸枣仁汤对抑郁症伴失眠患者睡眠质量的影响.方法:选取2022 年 4 月至 2023年3 月淄博市精神卫生中心收治的抑郁症伴失眠患者76 例作为研究对象,按随机数字表法分为观察组(n =38)和对照组(n =38),对照组给予常规西药治疗,观察组给予疏肝解郁安神汤联合酸枣仁汤治疗,疗程均为 4 周.治疗后,评估 2组患者的临床疗效、内分泌指标,包括促肾上腺皮质激素释放激素(CRH)、促性腺激素释放激素(Gn-RH)、促肾上腺皮质激素(ACTH)及促甲状腺激素释放激素(TRH).采用匹兹堡睡眠质量指数(PSQI)比较2 组患者干预前后睡眠质量的变化,采用汉密尔顿抑郁量表(HAMD),采用抑郁自评量表(SDS)比较 2 组患者干预前后抑郁状态的改善效果,采用蒙特利尔认知评估量表(MoCA)评估2 组患者的认知功能.结果:观察组的总有效率、蒙特利尔认知评估量表MoCA评分显著高于对照组,观察组的HAMD评分、内分泌指标水平、SDS评分、PSQI评分均显著低于对照组,差异均有统计学意义(均P＜0.05).结论:抑郁症伴失眠患者采用疏肝解郁安神汤联合酸枣仁汤效果显著,可有效缓解患者的抑郁状态,改善患者的内分泌水平、睡眠质量及认知功能,值得临床推广使用.
Abstract
Objective:To analyze the effect of Shugan Jieyu Anshen Tang combined with Suanzaoren Tang on the sleep quality of patients with depression and insomnia.Methods:A total of 76 patients with depression and insomnia admitted to the Zibo Mental Health Center from April 2022 to March 2023 were selected as the study subjects.They were randomly divided into an observation group(n =38)and a control group(n =38)using a random number table method.The control group was treated with conventional Western medicine,while the observation group was treated with Shugan Jieyu Anshen Tang combined with Suanzaoren Tang for 4 weeks.After treatment,evaluate the clinical efficacy and endocrine indicators of two groups of patients,including adrenocortico-tropin-releasing hormone(CRH),gonadotropin-releasing hormone(Gn-RH),adrenocorticotropin-releasing hormone(ACTH),and thyrotropin releasing hormone(TRH).The Pittsburgh Sleep Quality Index(PSQI)was used to compare the changes in sleep quali-ty before and after intervention between two groups of patients.The Hamilton Depression Scale(HAMD)was used,and the Self Rating Depression Scale(SDS)was used to compare the improvement effect of depression status before and after intervention be-tween the two groups of patients.The Montreal Cognitive Assessment Scale(MoCA)was used to evaluate the cognitive function of the two groups of patients.Results:The total effective rate and MoCA score of the Montreal Cognitive Assessment Scale in the ob-servation group were significantly higher than those in the control group.The HAMD score,endocrine index level,SDS score,and PSQI score of the observation group were significantly lower than those in the control group,and the differences between the two groups were statistically significant(P＜0.05).Conclusion:The combination of Shugan Jieyu Anshen Tang and Suanzaoren Tang has a significant effect on patients with depression and insomnia.It can effectively alleviate the patient's depressive state,improve their endocrine level,sleep quality,and cognitive function,and is worthy of clinical promotion and use.
关键词
疏肝解郁安神汤/酸枣仁汤/抑郁症伴失眠/睡眠质量/内分泌指标/抑郁程度/认知功能/临床疗效Key words
Shugan Jieyu Anshen Tang/Sour jujube kernel soup/Depression accompanied by insomnia/Sleep quality/Endo-crine indicators/Depression level/Cognitive function/Clinical efficacy引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据