Objective:To explore the clinical efficacy of terbutaline plus budesonide in the treatment of severe acute exacerbation of chronic obstructive pulmonary disease(AECOPD)patients.Methods:A total of 84 patients with severe AECOPD from Februar-y 2020 to March 2023 at the First People's Hospital of Taicang City were selected as the study subjects,and were randomly divid-ed into a control group and an observation group with 42 cases in each group,using a random number table method.The control group patients were given nebulized inhalation therapy of terbutaline sulfate on the basis of routine treatment,while the observation group patients were given nebulized therapy in combination with budesonide suspension on the basis of control group treat-ment.The effects of different medication methods on inflammatory mediators,sleep quality,and clinical efficacy of the two groups were compared.Results:There was no significant difference in the levels of inflammatory mediators between the two groups before treatment(Ps＞0.05).After treatment,the levels of C-reactive protein(CRP),interleukin-6(IL-6),and procalcitonin(PCT)in the observation group were lower than those in the control group,and the difference was statistically significant(Ps＜0.05).There was no statistically significant difference in sleep quality between the two groups of patients before treatment(P＞0.05).After treatment,the observation group had significantly better sleep time,number of awakenings,and Pittsburgh Sleep Quality Index(PSQI)scores than the control group,with statistically significant differences(Ps＜0.05).The clinical treatment efficiency of the observation group was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).Before treatment,there was no statistically significant difference in lung function between the two groups of patients(Ps＞0.05).After treatment,the observation group had higher levels of forced expiratory volume(FEV,),forced vital capacity(FVC),maximum mid expiratory flow rate(MMEF),and peak expiratory flow rate(PEF)than the control group,and the differences were statistically significant(Ps＜0.05).Conclusion:The combination therapy of terbutaline and budesonide can achieve significant clinical therapeutic effects and have a positive effect on the recovery of body health in severe AECOPD patients.
关键词
重症慢性阻塞性肺疾病急性加重/特布他林/布地奈德/炎症介质/睡眠质量
Key words
Severe acute exacerbation of chronic obstructive pulmonary disease(AECOPD)/Terbutaline/Budesonide/Inflam-matory mediators/Sleep quality
维普
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