Objective:To explore the effects and mechanisms of Poria cocos water extract,Panax notoginseng water extract and their extracts on sleep in mice.Methods:Direct sleep,prolonged sleep time with pentobarbital sodium,subthreshold dose hypnosis with pentobarbital sodium,and sleep latency with pentobarbital sodium were used to detect the changes in neurotransmitter content in the hypothalamus of mice,evaluate its impact on mouse sleep,and evaluate the safety of Poria cocos notoginseng water extract complex through acute toxicity experiments.Results:The results of each dose group of Poria cocos water extract,Panax notogin-seng water extract and their water extract complex showed that pentobarbital sodium induction can prolong the sleep time of mice.The sleep incidence of mice in each dose group of Poria cocos and Panax notoginseng water extract complex was significantly increased,and the difference was statistically significant(P＜0.05).Except for the low-dose group of Panax notoginseng water ex-tract,the sleep latency of other groups of mice was shortened,and the difference was statistically significant(P＜0.05).In addi-tion,the levels of 5-hydroxytryptamine(5-HT)in the hypothalamus and serum of mice in the middle and high-dose groups of Poria cocos and Panax notoginseng water extract complex were found to be correlated with-γ-Aminobutyric acid γ-The content of Ami-nobutyric acid(GABA)was significantly higher than that of the control group,and the difference was statistically significant(P＜0.05).It significantly increased the content of 5-HT and GABA in the hypothalamus of insomnia rats,regulated the change of the content of neurotransmitters in the hypothalamus,and did not produce toxicity.Conclusion:Pachycoia water extract,Notoginseng water extract and pachycoia Notoginseng water extract complex can improve sleep of mice by regulating neurotransmitter,and the complex composed of pachycoia water extract and Notoginseng water extract has synergistic effect and good safety.
维普
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