Objective:To analyze the effect of mindfulness training on negative emotions and sleep quality in maintenance hemo-dialysis patients.Methods:A total of 116 uremic patients with maintenance hemodialysis(MHD)admitted to the First Hospital of Quanzhou City,Fujian Province,from September 2022 to November 2023 were selected as the study subjects.They were randomly divided into observation and control groups using a random number table method,with 58 cases in each group.The control group received routine psychological care intervention,while the observation group received mindfulness training intervention based on routine psychological care intervention.The Hamilton Anxiety Scale(HAMA)and Hamilton Depression Scale(HAMD)were used to compare the improvement effects of anxiety and depression status between two groups of patients before and after interven-tion.The Asens Insomnia Scale(AIS)was used to compare the changes in sleep quality between the two groups of patients before and after intervention.Results:After eight weeks of intervention,the HAMA score and HAMD score of the observation group were significantly lower than those of the control group.After intervention,the AIS score of the observation group decreased significant-ly.At 4,8,and 12 weeks,the AIS score and the incidence of sleep disorders were significantly lower than those of the control group.The difference between the two groups was statistically significant(P<0.05).Conclusion:Mindfulness training can im-prove negative emotions,enhance the quality of sleep and reduce the incidence of sleep disorders in MHD patients,which is wor-thy of clinical promotion and application.