Objective:To observe the effects of psychological nursing combined with music on social anxiety and sleep of college students.Methods:A total of 120 college students(from March 2021 to December 2023)were randomly divided into an observa-tion group(60 cases)with psychological nursing combined with music and a control group(60 cases)with routine nursing.Results:Compared with the control group,the observation group had a higher score of mental health level,lower score of PSQI,higher score of quality of life,higher score of comfort,higher score of social anxiety,and higher score of satisfaction(P<0.05).Conclusion:The combination of psychological nursing and music can improve the level of mental health,social anxiety,and sleep quality,improve the quality of life and comfort,and the satisfaction is high,which is worth learning.