Objective:To study the effect of cognitive behavior intervention combined with music therapy on patients with depres-sion,focusing on the effect of such intervention on patients'sleep,depressive mood and mentality.Methods:A total of 92 patients with depression admitted to our hospital from January 2023 to December 2023 were divided into control group and observation group,46 cases each.The intervention measures taken by the observation group were music therapy+cognitive behavioral inter-vention,and the intervention measures taken by the control group were routine nursing.The sleep quality,depression degree and psychological state of patients in the two groups were assessed at two time points before and after intervention,and the evaluation results of various indicators were compared and analyzed.Results:The scores of anxiety,symptom self-rating scale,depression and sleep in 2 groups after intervention were all lower than before intervention(P<0.05),and the scores of anxiety,symptom self-rat-ing scale,depression and sleep in observation group after intervention were all lower than those in control group(P<0.05).Con-clusion:The combination of cognitive behavioral intervention and music therapy has significant advantages in the clinical nursing of patients with depression,and it has very important clinical value in improving the mental state and depression mood of patients and improving their sleep conditions.