Effect of Repetitive Transcranial Magnetic Stimulation For Depression Complicated with Sleep Disorder
陈巧云 1孙美鸽1
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作者信息
1. 泉州市第三医院,泉州,362100
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摘要
目的:分析重复经颅磁刺激(rTMS)在合并睡眠障碍抑郁症患者治疗中的应用效果.方法:选取2022年4月至2023年12月泉州市第三医院收治的抑郁症合并睡眠障碍患者78例作为研究对象,按照随机数字表法分为对照组和观察组,每组39例.对照组采用药物治疗,观察组采用药物治疗+低频rTMS治疗.比较2组治疗后抑郁症状、睡眠质量与心率变异性.抑郁症状采用汉密顿抑郁量表(HAMD)评价,睡眠质量采用匹兹堡睡眠质量指数(PSQI)评价.结果:观察组在4周、8周后HAMD低于对照组,差异有统计学意义(P＜0.05),PSQI与睡眠障碍发生率均显著较低,差异有统计学意义(P＜0.05).观察组4周后正常窦性心搏RR间期的标准差(SDNN)、24 h内每5 min RR间期平均值的标准差(SDANN)、总功率(TP)、高频(HF)、低频(LF)高于对照组,差异有统计学意义(P＜0.05).结论:低频rTMS可改善抑郁症合并睡眠障碍患者自主神经功能,减轻抑郁症状,减少睡眠障碍.
Abstract
Objective:To analyze the effect of rTMS in the treatment of depression complicated with sleep disorder.Methods:A total of 78 patients with depression combined with sleep disorder were divided into observation group(n=39)and control group(n=39)by random number table method.The control group received drug treatment,while the observation group received drug treatment+low-frequency rTMS therapy.The depression symptoms,sleep quality,and heart rate variability were compared after treatment.Depression was evaluated using the HAMD-24,and sleep quality was evaluated using PSQI.Results:Compared to the control group,HAMD score of observation group was significantly lower at 4 w and 8 w(P＜0.05),and the PSQI and incidence of sleep disorder were significantly lower(P＜0.05).SDNN,SDANN,TP,HF,and LF of observation group were higher than those of control group at 4 w(P＜0.05).Conclusion:Low-frequency rTMS can improve autonomic nervous function in patients with de-pression complicated with sleep disorder,alleviate depressive symptoms,and reduce sleep disorders.
关键词
抑郁症/睡眠障碍/重复经颅磁刺激/汉密顿抑郁量表/心率变异性
Key words
Depression/Sleep disorder/Repetitive transcranial magnetic stimulation/Hamilton Depression Scale/Heart rate variability
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