Observation of the Effects of Sacubitril Valsartan and Sleep Intervention on Sleep Parameters and Cardiac Function in Patients with Heart Failure and Insomnia
Observation of the Effects of Sacubitril Valsartan and Sleep Intervention on Sleep Parameters and Cardiac Function in Patients with Heart Failure and Insomnia
Objective:To observe the effects of sacubitril valsartan and sleep intervention on sleep parameters and cardiac func-tion in patients with heart failure and insomnia.Methods:A total of 200 patients with heart failure and insomnia in the fingers of Yongchun County Hospital,Quanzhou City,Fujian Province from May 2021 to May 2023 were selected as the study subjects.They were randomly divided into a control group and an observation group,with 100 cases in each group,using a random number table method.The control group received routine treatment,while the observation group received sacubitril valsartan and sleep manage-ment intervention.The SF-A30 multi-channel sleep monitor was used to detect the patient's awakening time,sleep latency,total sleep time,and sleep efficiency.The E-CUBE 15 color ultrasound diagnostic instrument was used to detect left ventricular ejection fraction,E-peak deceleration time,and left ventricular mass index before and after treatment.The serum tumor necrosis factor al-pha(TNF-alpha)level was measured using enzyme-linked immunosorbent assay;5 mL of fasting elbow vein blood was extracted before and after treatment,and the N-terminal B-type pronatriuretic peptide(NT proBNP)level was detected using electrochem-iluminescence method;Using radioimmunoassay to detect plasma renin activity(PRA)levels and comparing the clinical efficacy of two groups of patients.Results:After intervention,the awakening time and sleep latency of the observation group were signifi-cantly shorter than those of the control group.The sleep efficiency of the observation group was significantly higher than that of the control group,and the total sleep time was significantly longer.The left ventricular ejection fraction of the observation group was significantly higher than that of the control group.The E peak deceleration time and left ventricular mass index of the observation group were lower than those of the control group.The TNF-α,NT proBNP,and PRA content of the observation group were lower than those of the control group.The total effective rate of the observation group was significantly higher than that of the control group,and the differences between the two groups were statistically significant(P＜0.05).Conclusion:Sacubitril valsartan and sleep intervention can inhibit inflammation,improve heart function,ventricular remodeling,sleep parameters,enhance sleep quality and clinical efficacy in patients with heart failure and insomnia.It is worthy of clinical promotion and application.
关键词
沙库巴曲缬沙坦/睡眠干预/心力衰竭/失眠/炎症/心功能/睡眠参数
Key words
Sacubitril and valsartan/Sleep intervention/Heart failure/Insomnia/Inflammation/Heart function/Sleep parame-ters
维普
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