达格列净联合吡格列酮改善糖尿病患者血糖、血脂及睡眠的研究

Study on the Effect of Daggligin Combined with Pioglitazone on Blood Glucose,Blood Lipid and Sleep in Patients with Diabetes

李伟斌 ¹黄儒川 ¹黄文凤¹

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作者信息

1. 南安市中医院,南安,362300
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摘要

目的:探究临床对糖尿病患者治疗时按照达格列净联合吡格列酮进行治疗对患者血糖、血脂以及睡眠质量的影响.方法:选取2022年4月至2023年11月南安市中医院收治的糖尿病患者94例作为研究对象,按照随机数字表法分为对照组和观察组,每组47例.对照组行常规用药方案治疗,观察组采用达格列净联合吡格列酮治疗.观察比较患者血糖、血脂、睡眠质量改善情况.结果:针对患者餐后2 h血糖水平以及空腹血糖水平检测,治疗前无差异,治疗后观察组低于对照组,差异有统计学意义(P＜0.05).针对患者血脂水平检测,治疗前TG、TC以及LDL-C水平无差异,治疗后观察组较对照组低,差异有统计学意义(P＜0.05).对患者睡眠质量对比,PSQI量表评分治疗前无差异,治疗后观察组评分低于对照组,差异有统计学意义(P＜0.05).针对患者胰岛功能对比,胰岛B细胞功能指数、胰岛素抵抗指数治疗前无差异,治疗后观察组胰岛B细胞功能指数高于对照组,胰岛素抵抗指数低于对照组,差异有统计学意义(P＜0.05).结论:对糖尿病患者治疗时按照达格列净联合吡格列酮进行治疗,可以更加有效改善患者血糖、血脂水平,并提高患者治疗期间睡眠质量,有助于患者进行恢复.

Abstract

Objective:To explore the effect of dagglinide combined with pioglitazone on blood glucose,blood lipid and sleep qual-ity of patients with diabetes.Methods:From April 2022 to November 2023,94 patients with diabetes in our hospital were select-ed.They were randomly sequenced from 0 to 94 in Excel.The odd sequence was treated according to the conventional drug regi-men(47 cases,control group),and the even sequence was treated according to dagelin combined with pioglitazone(47 cases,ob-servation group).Comparison of improvements in blood sugar,blood lipids,and sleep quality among patients.Results:Regarding the detection of 2-hour postprandial blood glucose levels and fasting blood glucose levels in patients,there was no difference before treatment,but the observation group was lower than the control group after treatment(P＜0.05).Regarding the detection of blood lipid levels in patients,there was no difference in TG,TC,and LDL-C levels before treatment.After treatment,the observation group had lower levels than the control group(P＜0.05).Compared with the control group,there was no difference in the PSQI scale score before treatment regarding the sleep quality of patients.However,after treatment,the observation group's score was lower than that of the control group(P＜0.05).For comparison of pancreatic islet function in patients,pancreatic islets β There was no difference in cell function index and insulin resistance index before treatment,while the observation group had pancreatic islets after treatment β the cell function index was higher than the control group,while the insulin resistance index was lower than the control group(P＜0.05).Conclusion:In the treatment of diabetes patients,the combination of dagglinide and pioglitazone can more effectively improve the blood sugar and lipid levels of patients,increase the sleep quality of patients during treatment,and help patients recover.

关键词

达格列净/吡格列酮/糖尿病/血糖/血脂/睡眠/胰岛细胞/胰岛素抵抗指数

Key words

Dapagliflozin/Pioglitazone/Diabetes/Blood sugar/Blood lipids/Sleep/Islet cells/Insulin resistance index

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出版年

2024

世界睡眠医学杂志

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参考文献量12

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