Objective:To observe the effect of music intervention combined with ICU fuzzy consciousness assessment form(CAM-ICU)intervention on sleep improvement in ICU syndrome patients.Methods:A total of 84 ICU syndrome patients were admitted to Quanzhou First Hospital ICU from October 2022 to October 2023.Randomly group according to admission number,with an av-erage of 42 cases in the control group and observation group.The control group received routine care,while the observation group received music intervention combined with CAM-ICU intervention on this basis.Conduct a comprehensive evaluation based on e-motional state,degree of insomnia,and sleep quality.Results:After intervention,the hospital anxiety and depression scale(HADS)scores of the two groups of patients decreased compared to before the intervention(P<0.05);Compared with the con-trol group,the observation group had lower scores(P<0.05).After intervention,the severity index of insomnia(ISI-C)scores of the two groups of patients decreased compared to before intervention in the same group(P<0.05);Compared with the control group,the observation group had lower scores(P<0.05).After intervention,the Richards Campbell Sleep Scale(RSCQ)scores of the two groups of patients increased compared to the same group before intervention(P<0.05);Compared with the control group,the observation group had a higher score(P<0.05).Conclusion:Music intervention combined with CAM-ICU intervention can ef-fectively alleviate anxiety and depression,alleviate insomnia symptoms,and improve sleep conditions in ICU syndrome patients.