成人癫痫患者发生睡眠障碍的现状及其影响因素研究

Current Status and Influencing Factors of Sleep Disorders in Adult Patients with Epilepsy

陈红星¹

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作者信息

1. 福建三博福能脑科医院神经内科,福州,350001
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摘要

目的:分析成人癫痫患者睡眠障碍发生情况及其与认知功能、心理状态的相关性.方法:选取2019年1月至2023年12月福建三博福能脑科医院神经内科收治的癫痫患者87例作为研究对象,按照是否存在睡眠障碍分为睡眠障碍组(n=40)与无睡眠障碍组(n=47).收集统计所有患者的临床资料,采用匹兹堡睡眠指数量表(PSQI)评估睡眠情况,用简易精神状态评价量表(MMSE)评估认知功能,采用贝克抑郁量表第2版(BDI-Ⅱ)评估抑郁程度,用贝克焦虑量表(BAI)评估焦虑程度,统计睡眠障碍发生率,并用多因素Logistic回归分析成人癫痫患者发生睡眠障碍的影响因素,用Pearson分析PSQI与MMSE、BDI-Ⅱ及BAI评分的相关性.结果:本组共纳入87例患者,有45.98％(40/87)患者存在睡眠障碍;多因素Logistic回归分析显示,BDI-Ⅱ评分≥20分(OR=3.124)、BAI评分≥16分(OR=3.133)、认知功能障碍(OR=5.058)是影响癫痫患者发生睡眠障碍的独立危险因素(P＜0.05);Pearson相关性分析显示,PSQI评分与BDI-Ⅱ、BAI评分正相关(P＜0.05),与MMSE评分负相关(P＜0.05).结论:成人癫痫患者睡眠障碍发生率较高;认知功能障碍、焦虑、抑郁与成人癫痫患者睡眠障碍的发生明显相关,是其独立危险因素.

Abstract

Objective:To analyze the occurrence status of sleep disorders in adult patients with epilepsy and the correlation with cognitive function and psychological status.Methods:A total of 87 patients with epilepsy in the hospital were selected from Janu-ary 2019 to December 2023 as the research subjects.According to the existence of sleep disorders,they were divided into sleep disorder group(n=40)and no sleep disorder group(n=47).The clinical data of all patients were collected and statistically ana-lyzed.Pittsburgh Sleep Quality Index(PSQI)was used to evaluate sleep status.Mini-Mental State Examination(MMSE)was ap-plied to evaluate cognitive function.The degree of depression was assessed by Beck Depression Inventory-Ⅱ(BDI-Ⅱ),and the anxiety degree was evaluated by Beck Anxiety Inventory(BAI).The incidence rate of sleep disorders was counted.Multivariate Logistic regression analysis was performed to analyze the influencing factors of sleep disorders in adult patients with epilep-sy.Pearson analysis was used to analyze the correlation between PSQI and MMSE,BDI-Ⅱ and BAI.Results:A total of 87 patients were included in this group,and 45.98％(40/87)of patients had sleep disorders.Multivariate Logistic regression analysis showed that BDI-Ⅱ score≥20 points(OR=3.124),BAI score≥ 16 points(OR=3.133)and cognitive dysfunction(OR=5.058)were independent risk factors for sleep disorders in patients with epilepsy(P＜0.05).Pearson correlation analysis revealed that PSQI score was positively correlated with BDI-Ⅱ and BAI(P＜0.05),and was negatively correlated with MMSE score(P＜0.05).Conclusion:The incidence rate of sleep disorders in adult patients with epilepsy is higher.Cognitive dysfunction,anxiety and de-pression are significantly related to the occurrence of sleep disorders in adult patients with epilepsy,and are independent risk factors.

关键词

癫痫/成人/睡眠障碍/认知功能/心理状态/影响因素分析/简易精神状态评价量表/匹兹堡睡眠指数量表

Key words

Epilepsy/Adult/Sleep disorders/Cognitive function/Mental state/Analysis of influencing factors/Simple mental state assessment scale/Pittsburgh Sleep Index Scale

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出版年

2024

世界睡眠医学杂志

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参考文献量20

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