Objective:lo analyze the effects of aspirin and clopidogrel on sleep quality in elderly patients with coronary heart dis-ease.Methods:A total of 100 elderly patients with coronary heart disease enrolled in our hospital during 2022.1 to 2023.1 were divided into the control group(n=50,aspirin)and the study group(n=50,aspirin combined with clopidogrel)by computer lot-tery method,and the efficacy,sleep quality,inflammatory factors and adverse reactions were observed.Results:The efficacy of the control group was 84%,and the incidence of adverse reactions was 10%,and the study group was 98%and 4%,respectively.The efficacy of the control group was lower than that of the study group,and the data difference was statistically significant(P<0.05).The incidence of adverse reactions was higher in the observed group than in the control group(P<0.05).Before treat-ment,there was no statistical difference in sleep quality and inflammatory factors(P>0.05).After treatment,the indicators of the study group were better than control group,and the data differences were statistically significant(P<0.05).Conclusion:Aspirin combined with clopidogrel can improve the therapeutic effect,improve the sleep quality and inflammatory indicators of elderly pa-tients with coronary heart disease,and the adverse reactions do not change,which can be promoted.