Objective:To explore the effectiveness and value of non-invasive ventilation in the treatment of chronic obstructive pulmonary disease(COPD)with respiratory failure.Methods:A total of 70 COPD patients with respiratory failure admitted to the Respiratory and Critical Care Medicine Department of Ningde City Hospital Affiliated to Ningde Normal University from October 2022 to October 2023 were selected.The included samples were divided into two groups according to the random number table method.The control group(35 cases)received routine treatment,while the observation group(35 cases)received non-invasive ventilation treatment.The arterial blood gas parameters,lung function indicators,and sleep quality of the two groups were com-pared.Results:The observation group measured higher values of blood oxygen saturation(SaO2)and partial pressure of blood oxy-gen(PaO2),and lower values of partial pressure of carbon dioxide(PaCO2),the difference was statistically significant(P<0.05).After treatment,the highest expiratory flow rate(PEF),forced expiratory volume at 1 second(FEV1),forced vital capacity(FVC),and F EVV1/FVC index values were all higher in the observation group the difference was statistically significant(P<0.05).After treatment,the observation group had higher values of sleep efficiency and total sleep time indicators,while lower val-ues of awakening frequency and sleep latency indicators,the difference was statistically significant(P<0.05).Conclusion:The use of non-invasive ventilation in COPD patients with respiratory failure can have a positive impact on arterial blood gas parame-ters,lung function indicators,and sleep quality improvement.