Clinical Efficacy of Duloxetine Combined with Trazodone Hydrochloride in the Treatment of Anxiety and Depression Comorbidities after Ischemic Stroke in Elderly Patients
Clinical Efficacy of Duloxetine Combined with Trazodone Hydrochloride in the Treatment of Anxiety and Depression Comorbidities after Ischemic Stroke in Elderly Patients
Objective:To explore the clinical efficacy of duloxetine combined with trazodone hydrochloride in the treatment of anxiety and depression comorbidities after ischemic stroke in elderly patients.Methods:A total of 120 elderly patients with anxie-ty and depression comorbidity after ischemic stroke admitted to Department of Neurology,the Second Hospital of Longyan City,Fu-jian Province from January 2021 to January 2023 were selected as the study objects,and were divided into control group and ob-servation group according to random number table method,with 60 cases in each group.The control group received treatment with trazodone hydrochloride tablets,while the observation group received additional treatment with duloxetine hydrochloride enteric coated capsules on this basis.Both groups received continuous treatment for 1 month.The clinical efficacy,neurotransmitter lev-els,anxiety and depression,sleep quality and adverse reactions were compared between the two groups.Results:The total effective rate of observation group was 95.00％,which was higher than that of control group(81.67％)(P＜0.05).After treatment,norep-inephrine(NE),5-hydroxytryptamine(5-HT)and dopamine(DA)in observation group were higher than those in control group.Self-rating Anxiety Scale(SAS)scores,Self-rating Depression Scale(SDS)scores,Pittsburgh Sleep Quality Index(PSQI)scores were lower than control group(P＜0.05).There was no statistically significant difference in the comparison of adverse re-actions between the two groups(P＞0.05).Conclusion:The combination of duloxetine and trazodone hydrochloride in the treat-ment of anxiety and depression comorbidities in elderly patients with ischemic stroke has obvious clinical effects,which can effec-tively improve the level of neurotransmitters,reduce the degree of anxiety and depression,and improve the quality of sleep.
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