Study on the Effect of Dazhu Rhodiola Capsule Plus Plus Plus Plus Tiotropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Sleep Disorders in the Elderly
Study on the Effect of Dazhu Rhodiola Capsule Plus Plus Plus Plus Tiotropium Bromide in the Treatment of Chronic Obstructive Pulmonary Disease Complicated with Sleep Disorders in the Elderly
Objective:To observe the therapeutic effect of Dazhurodiola capsule plus or without tiotropium bromide in elderly pa-tients with chronic obstructive pulmonary disease(COPD)complicated with sleep disorders.Methods:A total of 80 elderly pa-tients with COPD complicated with sleep disorder admitted to Xiapu County Hospital,Ningde City,Fujian Province from May 2022 to May 2023 were selected as the study objects,and were divided into control group and observation group according to random number table method,with 40 cases in each group.The control group was treated with tiotropium bromide,and the observation group was treated with Dazhurodiola capsule on the basis of the control group.The therapeutic effects of the two groups were com-pared.The maximum expiratory flow rate(PEF),interrupted expiratory flow rate(MMEF),maximum expiratory volume in one sec-ond(FEV1)and ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)of the two groups before and after treatment were measured by the Sence Vmax220 pulmonary function tester.The indexes of respiratory disorder and oxidative stress were compared between the two groups,and the Pittsburgh Sleep Quality index(PSQI)was used to compare the difference of sleep quality between the two groups.Results:After intervention,the total effective rate of the observation group was significant-ly higher than that of the control group,and the difference between the two groups was statistically significant(P＜0.05).The maximum expiratory flow rate(PEF),interrupted expiratory flow rate(MMEF),maximum expiratory volume in one second(FEV1)and ratio of forced expiratory volume in one second to forced vital capacity(FEV1/FVC)in observation group were significantly higher than those in control group,and the difference was statistically significant(P＜0.05).After intervention,the peripheral re-sistance(Rp),total respiratory viscosity resistance(R5),total respiratory impedance(Zrs),total antioxidant capacity(TAC),su-peroxide dismutase(SOD)level and malondialdehyde(MDA)in observation group were significantly lower than those in control group,and the difference was statistically significant(P＜0.05).After the intervention,the Pittsburgh Sleep quality index(PSQI)score of the observation group was significantly lower than that of the control group,and the difference between the two groups was statistically significant(P＜0.05).Conclusion:In the treatment of elderly COPD complicated with sleep disorders,the effect of Dazhurodisea capsule plus or less combined with tiotropium bromide inhalation is more significant,which can effectively improve the oxidative stress index and the degree of respiratory disorder,which is of great significance for improving lung function and sleep quality,and is worthy of promotion and application.
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