Objective:To observe the effect of comprehensive nursing on sleep quality of epilepsy patients.Methods:Seventy pa-tients with epilepsy admitted to the neurosurgery department of the Second Longyan Hospital from June 2022 to June 2023 were selected as the study objects,and were divided into control group and observation group according to random number table meth-od,with 35 patients in each group.The control group received routine nursing,the observation group received comprehensive nurs-ing,and the sleep quality and psychological status of the two groups were compared after nursing.Results:After nursing,the scores of sleep time,sleep quality and sleep efficiency in 2 groups were lower than those before nursing(P<0.05),and the obser-vation group was significantly lower than the control group(P<0.05).After nursing,the scores of Self-rating Anxiety Scale(SAS)and Self-rating Depression Scale(SDS)in 2 groups were lower than those before nursing(P<0.05),and those of the observation group was significantly lower than the control group(P<0.05).The recovery of sleep time,sleep quality and sleep efficiency were significantly higher than those of control group(P<0.05).After nursing,the scores of SAS and SDS in observation group was low-er(P<0.05).Conclusion:Comprehensive care can effectively improve the sleep quality of epilepsy patients,alleviate anxiety and depression,so that they maintain a good state of mind to receive treatment,which is worthy of promoting.